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3000 BCE
2900 BCE
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3000 BCE - 2000 BCE: First human presence recorded on Kos.
1600 BCE - 1200 BCE: The Mycenaean settlement of Serayia flourishes on Kos.
480 BCE: The Tyrant Kadmos permits the establishment of democratic government on Kos.
412 BCE: The Spartan general Astyochus sacks Kos.
411 BCE: The Athenian general Themistocles builds fortifications on Kos.
350 BCE: Mausolus, ruler of Caria, invades Kos.
350 BCE: The Ascelpeion is built on Kos.
340 BCE: The Greek poet and scholar Philitas is born on Kos.
332 BCE: Amphoterus, admiral of Alexander the Great, takes possession of Kos.
242 BCE: The games held in honour of Asclepius on Kos are given Panhellenic status.
102 BCE: Cleopatra II of Egypt sends her treasury to Kos.
100 BCE: Coins of Kos and Thespiai depict a lyre on their reverse side.