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1080 CE
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1080 CE: The Hospital of Saint John in Jerusalem is established by what would become the Knights Hospitaller.
1100 CE: The Order of Hospitallers of St. Anthony is established in Grenoble, France.
1113 CE: The Knights Hospitaller are recognised as a religious order by Pope Paschal II.
1113 CE: The Blessed Gerard is officially appointed the first master of the Knights Hospitaller.
1120 CE: Raymond du Puy becomes master of the Knights Hospitaller.
1122 CE: The Knights Hospitaller establish a hospital in Utrecht.
1130 CE: The first Rule of the Knights Hospitaller is compiled.
1135 CE - 1154 CE: The Church grants the Knights Hospitaller order independence from any local religious authority.
1136 CE: The Knights Hospitaller are given the castle of Beth Gibelin, Jerusalem.
1144 CE: The Knights Hospitaller acquire the castle of Krak des Chevaliers in Syria.
1186 CE: The Knights Hospitaller gain control of Marqab (Margat) castle in Syria.
1188 CE: Saladin besieges the Knights Hospitaller castle of Krak des Chevaliers but withdraws to meet the Third Crusade.
1191 CE: After the fall of Jerusalem the Knights Hospitaller move their base to Acre.
1202 CE: An earthquake damages the castle of Krak des Chevaliers in Syria which is then rebuilt and enlarged by the Knights Hospitaller.
1271 CE: Al-Zahir Baibars, Sultan of Egypt and Syria, captures the Knights Hospitaller castle of Krak des Chevaliers.
1306 CE: The Knights Hospitaller, looking for a new base, attack Byzantine Rhodes.
1309 CE: The Knights Hospitaller establish a new headquarters on Rhodes.
1397 CE: The Knights Hospitaller buy Corinth from the Byzantine Empire.
1403 CE: The Knights Hospitaller lose control of Corinth to the Ottomans.
1530 CE: The Knights Hospitaller establish a new headquarters on Malta.